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目的:探讨老老年患者颈动脉中层厚度(IMT)及其相关危险因素的关系,为老老年患者心脑血管疾病的预防及治疗提供临床参考。方法:根据年龄将139例老老年患者纳入分析,有血糖、血压、血脂代谢紊乱的123例作为观察组,无血糖、血压、血脂代谢紊乱的16例作为对照组,分别进行颈动脉超声检查、动态血压监测、糖化血红蛋白及血脂等生化指标检查,并结合临床资料进行分析。结果:老老年患者均无一例外地存在着IMT增厚,在相同的年龄情况下,吸烟史、血脂紊乱、糖调节异常、血管炎症反应与IMT的增厚呈正相关,各组未显示出统计学差异,IMT的发生发展与年龄、性别、吸烟史、血糖、血压控制水平及血脂紊乱等因素在两组对照中均未显示出统计学差异,多因素Logistic回归分析,显示年龄、吸烟史及病程为危险因素(OR为0.500～1.196)。结论:老老年患者均不同程度地存在着IMT增厚,其中增龄是其最主要的危险因素,但是对合并有血糖、血压、血脂代谢紊乱的老老年患者也应该积极重视对各种危险因素的筛选和干预,特别在疾病发生发展的早期可能对延缓病变的进展和减少心脑血管事件有一定意义,可是其用药的安全性在该类患者就显得尤为重要。
Objective: To investigate the relationship between carotid artery middle thickness (IMT) and its related risk factors in the elderly patients and to provide clinical reference for the prevention and treatment of cardiovascular and cerebrovascular diseases in the elderly. Methods: According to the age of 139 elderly patients were included in the analysis, with blood glucose, blood pressure, dyslipidemia in 123 cases as the observation group, no blood glucose, blood pressure, dyslipidemia in 16 cases as control group, respectively, carotid ultrasound, Ambulatory blood pressure monitoring, glycosylated hemoglobin and lipids and other biochemical indicators, combined with clinical data analysis. Results: There was an exception of IMT thickened in the elderly patients, smoking history, dyslipidemia, abnormal glucose regulation, vascular inflammation and IMT thickening in the same age group, no statistics were found in each group There were no significant differences in the occurrence and development of IMT, age, sex, smoking history, blood glucose, blood pressure control and dyslipidemia between the two groups. Multivariate Logistic regression analysis showed that age, smoking history and Course of disease as a risk factor (OR 0.500 ~ 1.196). Conclusion: The elderly patients are varying degrees of IMT thickened, of which aging is the most important risk factor, but for elderly patients with metabolic disorders of blood glucose, blood pressure, blood lipids should also pay attention to a variety of risk factors Screening and intervention, especially in the early stage of disease development may delay the progression of the lesion and reduce cardiovascular and cerebrovascular events have some significance, but the safety of its medication in this type of patients is particularly important.