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目的:了解乙型肝炎患者应用干扰素(IFN)治疗后对垂体前叶分泌促激素、皮质醇和细胞因子的影响。方法:采用放射性免疫和ELISA法测定血中生长激素(GH)、泌乳素(PRL)、促肾上腺皮质激素(ACTH)、黄体生成素(LH)、促卵泡激素(FSH)和促甲状腺激素(TSH)、皮质醇、白细胞介素-2(IL-2)、IL-6和肿瘤坏死因子-α(TNF-α)。结果:应用IFN后,乙型肝炎患者血清中GH、ACTH和皮质醇水平呈现显著性的升高(P<0.05～0.005),而PRL、LH、FSH和TSH则无明显改变;细胞因子IL-2、IL-6和TNF-α均较对照组显著性升高(P<0.01)。结论:应用IFN治疗乙型肝炎后可以发现,机体内的免疫系统和内分泌系统之间是相互影响相互作用的。
Objective: To investigate the effect of interferon (IFN) on the secretion of progesterone, cortisol and cytokines in the anterior pituitary of hepatitis B patients. Methods: Serum GH, PRL, ACTH, LH, FSH and TSH were measured by radioimmunoassay and ELISA. ), Cortisol, interleukin-2 (IL-2), IL-6, and tumor necrosis factor-α (TNF-α). Results: The serum levels of GH, ACTH and cortisol in patients with hepatitis B increased significantly (P <0.05-0.005), while the levels of PRL, LH, FSH and TSH did not change significantly after IFN treatment. The levels of cytokines IL- 2, IL-6 and TNF-α were significantly higher than the control group (P <0.01). Conclusion: The application of IFN in the treatment of hepatitis B can be found in the body’s immune system and the interaction between the endocrine system is the interaction.