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用透射电镜对不同治疗剂量环孢素Ａ（ＣｙｃｌｏｓｐｏｒｉｎＡ，ＣｙＡ）对大鼠睾丸及肾上腺的作用进行了现实。结果：ＣｙＡ１０ｍｇ／ｋｇ可抑制睾丸生精上皮及精子的发育。ＣｙＡ２０ｍｇ／ｋｇ可引起生精上皮，精子及肾上腺皮质细胞结构改变。表现在核浓缩，线粒体扩张、破裂，溶酶体增多，脂滴空化及局部胞质坏死物质团块等。实验各组的肾上腺髓质都有明显变化，表现为Ⅰ、Ⅱ型细胞不同程度浓缩致密，线粒体扩张，溶酶体增多，内分泌颗粒肿大、破裂，电子密度降低等。提示：在临床应用ＣｙＡ治疗时，应注意对睾丸及肾上腺损伤作用。
The effects of different therapeutic doses of Cyclosporin A (CyA) on the testes and adrenals of rats were observed by transmission electron microscopy. Results: CyA 10 mg / kg inhibited the development of spermatogenic epithelium and sperm in testis. CyA 20mg / kg can cause changes in spermatogenic epithelium, sperm and adrenal cortex cells. Performance in the nuclear enrichment, mitochondrial expansion, rupture, increased lysosomes, lipid droplets cavitation and local cytoplasmic necrosis of the material mass. The adrenal medulla of each group had obvious changes, which showed that the type I and type II cells were concentrated and densified to varying degrees, the mitochondria were expanded, the lysosomes were increased, the endocrine granules were enlarged, ruptured and the electron density was reduced. Tip: CyA in clinical treatment, should pay attention to the testis and adrenal injury.