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采用病理形态学方法观察了饮水中舍不同剂量膦氧氮丙啶（ＭＡＰＯ）１６、８、４及０ｍｇ·Ｌ￣（－１）对３０１只Ｗｉｓｔａｒ大鼠的诱癌作用，历时４１５ｄ。大剂量组（经推算每天约口服６．４—８０ｍｇ·ｋｇ￣（－１））的３６只中途死亡动物中有７只发生淋巴造血组织的恶性肿瘤，包括３的淋巴细胞白血病、１例粒细胞白血病、１例淋巴肉瘤和２的网状细胞肉瘤。而３９只该组活杀动物及其它各组动物（包括７６只对照组动物）均未见此类恶性肿瘤。以上结果支持Ｇａｉｎｅｓ等提出的观点，即一定量的ＭＡＰＯ长期口服可能诱发大鼠淋巴造血组织的恶性肿瘤。讨论了ＭＡＰＯ诱发此类肿瘤的特点。
Histopathological methods were used to observe the carcinogenic effects of various dosages of phosphinoxazid (MAPO) at doses of 16,8, 4 and 0 mg · L ~ (-1) on 301 Wistar rats, which lasted 415 days. High-dose group (estimated to be oral about 6.4-80mg · kg ~ (-1) daily) of 36 animals died of lymphatic hematopoietic malignancy, including 3 lymphoblastic leukemia, 1 case of granulomatosis Cell leukemia, 1 case of lymphosarcoma and 2 reticulocytic sarcoma. However, none of the 39 animals killed in this group and all other animals (including 76 control animals) showed no such malignancy. The above results support Gaines and others put forward the view that a certain amount of long-term oral administration of MAPO may induce lymphoid hematopoietic malignancies in rats. The characteristics of MAPO-induced tumors are discussed.