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与感染有关的早产其特点是羊水中炎性细胞因子(包括IL-1、TNF-α、IL-6、IL-8、MIP-1α、GRPOα)浓度增高,提示这一过程伴随着强烈的子宫内炎症反应。白细胞介素10(IL-10)的释放是炎症的特点之一。在炎症过程中,其出现通常较晚,可使宿主对入侵的病原因子进行充分的应答。与感染有关的早产通常是突发的,在分娩之前不发生IL-10应答,推测与感染相关的早产不以产生IL-10为特点。为确定分娩及与炎症有关的早产羊水中IL-10浓度是否增高,收集如下羊水标本:足月妊娠未分娩孕妇42例,
Infections related to preterm birth are characterized by increased levels of inflammatory cytokines (including IL-1, TNF-α, IL-6, IL-8, MIP-1α, GRPOα) in amniotic fluid, suggesting that this process is accompanied by a strong uterus Internal inflammation. Interleukin-10 (IL-10) release is one of the hallmarks of inflammation. In the inflammatory process, it usually appears later, allowing the host to fully respond to the invasion of the pathogenic factor. Preterm births associated with infection are usually sudden and no IL-10 response occurs prior to delivery, suggesting that infection-related preterm births are not characterized by production of IL-10. In order to determine whether the IL-10 concentration in preterm amniotic fluid associated with delivery and inflammation is elevated, the following amniotic fluid samples were collected: 42 pregnant women without term delivery,