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采用MNNG加热损伤诱发大鼠胃粘膜异型增生,并运用具有益气健脾、滋肝补肾、清热解毒作用的中药胃尔康进行预防性治疗,结果发现,胃尔康能明显降低大鼠胃粘膜异型增生的发生率(P<0.01.P<0.05),且随剂量的增加这种作用更加明显,提示胃尔康能预防大鼠胃粘膜异型增生的发生,对致癌剂MNNG的致变作用有明显的阻断作用。
Using MNNG heat injury to induce dysplasia of gastric mucosa in rats, and the use of Chinese medicine Weierkang with Yiqi Jianpi, Zigan Bushen, detoxification and detoxification for preventive treatment, found that Gascon can significantly reduce the gastric mucosa of rats The incidence of dysplasia (P<0.01. P<0.05), and this effect was more pronounced with increasing doses, suggesting that Gastro-Chemical can prevent the occurrence of dysplasia of gastric mucosa in rats, and there is a mutagenic effect of carcinogen MNNG. Obvious blocking effect.