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应用免疫电镜对四氯化碳诱发大鼠肝硬化中纤维联接蛋白的演变进行了定位研究,发现在正常肝组织内纤维联接蛋白主要位于血窦内皮细胞表面、肝细胞血窦缘的微绒毛表面和Disse间隙内。在肝硬化发生的早、中期纤维联接蛋白在Disse间隙内增加显著,电镜下可见位于Disse间隙内的过渡细胞;在后期部分肝窦毛细血管化形成,纤维联接蛋白在Disse间隙内沉积减少。结果表明,纤维联接蛋白在Disse间隙内沉积可能影响贮脂细胞产生胶原,并介导胶原在该部位沉积增多,致肝窦毛细血管化,这是肝功减低的主要原因之一。
The localization of fibronectin in cirrhotic rats induced by carbon tetrachloride was studied by immunoelectron microscopy. It was found that the fibronectin was located mainly on the surface of sinusoidal endothelial cells in the normal liver tissue, and the microvilli surface And Disse gap. The early and mid-term fibronectin increased significantly in the Disse gap and the transitional cells located in the Disse gap under electron microscopy. In the latter part of the hepatic sinusoidogenesis, the fibroectin deposition decreased in the Disse gap. The results show that the deposition of fibronectin in the Disse gap may affect the collagen production of fat-storing cells and mediate the deposition of collagen in the area, resulting in hepatic sinusoidal capillary, which is one of the main reasons for the reduction of liver function.