A case of gas gangrene in an immunosuppressed Crohn's patient

• 作 者: Natalie Kiel Vincent Ho Andrew Pascoe
• 机 构: Department of Gastroenterology,Princess Alexandra Hospital,Brisbane,4102 Queensland,Australia,
• 出 处: World Journal of Gastroenterology
• 发表日期: 2011年33期
• 关键词: Clostridium completion vomiting diarrhea antibiotic profound emergency trauma cu

Clostridium septicum(C.septicum)gas gangrene is well documented in the literature,typically in the setting of trauma or immunosuppression.In this paper,we report a unique case of spontaneous clostridial myonecrosis in a patient with Crohn’s disease and sulfasalazineinduced neutropenia.The patient presented with left thigh pain,vomiting and diarrhea.Blood tests demonstrated a profound neutropenia,and magnetic resonance imaging of the thigh confirmed extensive myonecrosis.The patient underwent emergency hip disarticulation,followed by hemicolectomy.C.septicum was cultured from the blood.Following completion of antibiotic therapy,the patient developed myonecrosis of the right pectoral muscle necessitating further debridement,and remains on lifelong prophylactic antibiotic therapy.

Clostridium septicum (C. septicum) gas gangrene is well documented in the literature, typically in the setting of trauma or immunosuppression. This paper, we report a unique case of spontaneous clostridial myonecrosis in a patient with Crohn’s disease and sulfasalazine induced uutropenia. presented with left thigh pain, vomiting and diarrhea.Blood tests demonstrated a profound neutropenia, and magnetic resonance imaging of the thighs extensive myonecrosis.The patient underwent emergency hip disarticulation, followed by hemicolectomy .C.septicum was cultured from the blood. of antibiotic therapy, the patient developed myonecrosis of the right pectoral muscle necessitating further debridement, and remains on lifelong prophylactic antibiotic therapy.