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目的探讨超敏C反应蛋白(hs-CRP)、血浆活化蛋白C抵抗(APCR)与妊娠期高血压疾病(HDCP)的相关性,为临床HDCP的诊治提供理论基础。方法选取HDCP患者120例作为观察组,其中包括妊娠期高血压患者62例、子痫前期轻度患者28例、子痫前期重度患者30例;另随机选取120例同一时期正常孕晚期孕妇作为对照组。测定各组孕妇血清hs-CRP水平及血浆APCR的阳性率,并对上述指标与HDCP的发病进行相关性的探讨。结果与对照组比较,观察组血清hs-CRP水平、血浆APCR阳性率(33.3%)明显提高,差异均有统计学意义(P<0.05);观察组患者随着病情的加重,其血清hs-CRP水平逐渐提高,血浆APCR的阳性率逐渐提高,差异均有统计学意义(P<0.05)。结论妊娠期高血压患者血清hs-CRP水平及血浆APCR的阳性率会随着病情的加重而逐步提高,密切监测其变化对HDCP患者的预防、诊治等均具有极大的临床意义。
Objective To investigate the correlation between hs-CRP, APCR and HDCP, and to provide a theoretical basis for clinical diagnosis and treatment of HDCP. Methods 120 patients with HDCP were selected as the observation group, including 62 cases of hypertensive disorder complicating pregnancy, 28 cases of mild preeclampsia and 30 cases of severe preeclampsia. Another 120 cases of normal pregnant women of the same period were randomly selected as control group. Serum levels of hs-CRP and APCR positive rate in each group were determined, and the correlation between the above indexes and the incidence of HDCP was discussed. Results Compared with the control group, the serum hs-CRP level and the positive rate of APCR in plasma (33.3%) in the observation group were significantly increased (P <0.05). As the disease progressed, the hs- The level of CRP gradually increased, and the positive rate of plasma APCR gradually increased, the differences were statistically significant (P <0.05). Conclusion The serum hs-CRP level and the positive rate of plasma APCR in patients with gestational hypertension will gradually increase with the progression of the disease. Close monitoring of these changes has great clinical significance in the prevention, diagnosis and treatment of HDCP.