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采用部分肾切除的方法造成轻中度肾衰鼠动物模型,分成:黄芪和辅酶Q_(10)配伍、黄芪或辅酶Q_(10)及生理盐水对照四组,以观察上述药物对肾功能及病理组织学的影响。结果表明:单用黄芪或辅酶Q_(10)以及黄芪与辅酶Q_(10)配伍均可改善轻、中度肾衰,尤以后者对UN、Cr和CIn的作用最明显,单用黄芪或辅酶Q_(10)组的肾组织经电镜观察,病理改变均较对照组明显为轻;而对照组肾功能亦示有明显的恢复。认为这正是某些药物可能延缓早期肾衰进入终末期的内在基础。
The partial nephrectomy method was used to create the animal model of mild to moderate renal failure, divided into four groups: Astragalus membranaceus and Coenzyme Q_(10) compatibility, Astragalus membranaceus or Coenzyme Q_(10) and saline control group to observe the above-mentioned drugs on renal function and pathology. Histological influence. The results showed that the use of Astragalus membranaceus or coenzyme Q10 alone, and the compatibility of Astragalus membranaceus with coenzyme Q10 could improve mild to moderate renal failure, especially in the latter, the most obvious effect on UN, Cr and CIn, and the use of astragalus or coenzyme alone. The renal tissues of the Q10 group were observed by electron microscopy, and the pathological changes were significantly lighter than those in the control group. The renal function in the control group also showed significant recovery. It is believed that this is the intrinsic basis that certain drugs may delay the early stage of renal failure into the final period.