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抗菌药物在感染部位的穿透,对确保抗菌药物发挥其良好的效力以及在感染部位维持适宜的时间起着重要作用。测定间质液中抗菌药物的含量可直接反映其在血管外间隙,即感染部位的透入能力。负压吸引水疱(Suction blister)技术可作为测试间质液中抗生素浓度的可靠方法。此项技术系采用负压吸引装置在受试者腹部两侧皮肤负压吸引产生水疱,每个水疱内约含间质液30～50μl,供取样用。
The penetration of antibacterials at the site of infection plays an important role in ensuring that antibacterials exert their good effectiveness and maintain an appropriate time at the site of infection. Determination of interstitial fluid antibacterial drug content can directly reflect its extravascular space, that is, the penetration of the site of infection. Suction blister technique is a reliable method of testing antibiotic concentrations in interstitial fluid. This technology is the use of negative pressure suction device in the subjects of the skin on both sides of the abdomen to produce negative pressure suction blisters, each containing about 30 ~ 50μl interstitial fluid for sampling.