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本文采用血源乙肝疫苗单独或加用HBIG免疫HBsAg阳性无症状携带者(ASC)母亲的新生儿。经5年随访,63例儿童中受到保护者60例(95.2%),3例儿童HBsAg转阳;抗-HBs持续阳性者50例(79.4%)。免疫接种后抗-HBs的有效保护水平以第一年为最高,以后抗-HBs滴度逐年下降。乙肝疫苗加用HBIG组在第4或第5年时给予加强针较为适宜;单独注射乙肝疫苗组于第3年时给予加强接种。经加强注射后大部分儿童抗-HBs转阳率及滴度仍可上升。本组对免疫接种无反应者约占16%,对他们每年给予注射乙肝疫苗一次,HBsAg在随访期一直为阴性。
In this paper, newborns of HBsAg-positive asymptomatic carriers (ASC) were immunized with blood-borne hepatitis B vaccine alone or with HBIG. After 5 years of follow-up, 60 (95.2%) of the 63 children were protected, and 3 children had positive HBsAg; 50 (79.4%) were persistent positive of anti-HBs. After immunization, the effective protection level of anti-HBs was the highest in the first year, and the titer of anti-HBs decreased year by year later. Hepatitis B vaccine plus HBIG group at the 4th or 5th year to give more appropriate needle; hepatitis B vaccine alone was given in the third year of intensive vaccination. After intensive injection, the majority of children with anti-HBs positive rate and titer can still rise. This group of immunized non-responders accounted for about 16% of their annual injection of hepatitis B vaccine once, HBsAg in the follow-up period has been negative.