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目的:探讨促红细胞生成素(EPO)治疗新生儿缺氧缺血性脑病(HIE)的疗效和安全性。方法:将生后72 h内的中重度HIE患儿32例随机分为对照组和治疗组各16例,对照组按常规治疗,治疗组另给予EPO500 U/(kg·次),每周3次,共2周,比较两组生后7d、14d、28d新生儿行为神经评分(NBNA)。结果:与对照组比较,治疗组生后7 d、14 d、28 d的NBNA评分及格者明显增多,治疗过程中患儿无明显不良反应。结论:EPO可促进HIE患儿神经功能的早期恢复,且对其它系统无不良影响。
Objective: To investigate the efficacy and safety of erythropoietin (EPO) in the treatment of neonatal hypoxic-ischemic encephalopathy (HIE). Methods: Thirty-two cases of moderate and severe HIE within 72 hours after birth were randomly divided into control group and treatment group, 16 cases in each group. The control group was given conventional treatment of EPO 500 U / (kg · times) Times for 2 weeks. The neonatal behavioral neurological score (NBNA) was compared between the two groups at 7d, 14d and 28d after birth. Results: Compared with the control group, the NBNA score of the treatment group at 7 d, 14 d and 28 d after birth significantly increased, and there was no obvious adverse reaction in the treatment. Conclusion: EPO can promote the early recovery of neurological function in children with HIE and has no adverse effect on other systems.