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目的:探讨颈部低度迷走神经刺激对老年房颤患者血清C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)及基质金属蛋白酶-9(MMP-9)、基质金属蛋白酶抑制剂-1(TIMP-1)的影响。方法:选取我院收治的老年房颤患者126例,根据治疗方法的不同分为两组。对照组63例,予常规治疗,日1次,7天为1个疗程,治疗2个疗程;实验组63例,在对照组的基础上加以颈部低度迷走神经刺激术。治疗后,观察并比较两组患者的CRP、TNF-α及MMP-9、TIMP-1的变化情况。结果:治疗后,两组患者的血清CRP、TNF-α、MMP-9及TIMP-1均较治疗前显著降低,且实验组显著低于对照组,差异均有统计学意义(P<0.05)。实验组治疗后6个月内房颤的发生率显著降低,差异均有统计学意义(P<0.05)。结论:颈部低度迷走神经刺激能够有效降低老年房颤患者的复发率,这可能与其降低血清CRP、TNF-α,MMP-9、TIMP-1的水平有关。
Objective: To investigate the effect of low cervical vagus nerve stimulation on serum C-reactive protein (CRP), tumor necrosis factor-α (TNF-α) and matrix metalloproteinase-9 (MMP-9), matrix metalloproteinase inhibitor- 1 (TIMP-1) effects. Methods: A total of 126 elderly patients with atrial fibrillation admitted to our hospital were selected and divided into two groups according to the different treatment methods. Control group of 63 cases, to conventional treatment, day 1, 7 days for a course of treatment for 2 courses; experimental group of 63 cases, in the control group based on the neck low vagus nerve stimulation. After treatment, the changes of CRP, TNF-α, MMP-9 and TIMP-1 in two groups were observed and compared. Results: After treatment, the levels of serum CRP, TNF-α, MMP-9 and TIMP-1 in the two groups were significantly lower than those before treatment, and the levels in the experimental group were significantly lower than those in the control group (P <0.05) . The incidence of atrial fibrillation within 6 months after treatment in experimental group was significantly lower (P <0.05). CONCLUSION: Low neck vagal nerve stimulation can effectively reduce the relapse rate of elderly patients with atrial fibrillation, which may be related to its lower level of serum CRP, TNF-α, MMP-9 and TIMP-1.