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目的观察国产奥美拉唑(OME)联用庆大霉素(GEN)治疗幽门螺杆菌(Hp)阳性的十二指肠球部溃疡(DU)的疗效。方法对经胃镜检查确诊为Hp阳性的DU患者180例,采用奥美拉唑(奥克,OME)加庆大霉素(GEN)治疗,并以两种药物单用作为对照,分别观察2周和4周,分析其治疗效果。结果OME单独用药有效率和Hp清除率在2周、4周分别为72.4%、51.7%和80.7%、57.9%。GEN单独用药有效率和Hp清除率在2周、4周分别为48.3%、34.5%和51.8%、37.5%,两药联用的有效率和Hp清除率在2周、4周分别高达89.4%、87.7%和100%、93.0%,OME+GEN组2周和4周治疗DU的有效率和Hp清除率明显高于GEN组和OME组(P<0.01和P<0.05);OME组2周、4周治疗DU的有效率及Hp清除明显高于组GEN组(P<0.01和P<0.05),未见明显的副作用。结论OME和GEN联合治疗Hp感染的Du患者有效率和Hp清除率高、经济、安全可靠,值得基层临床应用推广。
Objective To observe the curative effect of homemade omeprazole (OME) combined with gentamicin (GEN) on Helicobacter pylori (Hp) positive duodenal ulcer (DU). Methods A total of 180 Hp-positive DU patients diagnosed by gastroscopy were treated with omeprazole (OME) and gentamicin (GEN). Two drugs And 4 weeks, analyze the treatment effect. Results The effective rate of OME alone and the clearance rate of Hp were 72.4%, 51.7% and 80.7% and 57.9% at 2 weeks and 4 weeks respectively. GEN alone and Hp clearance rates were 48.3%, 34.5% and 51.8%, 37.5% at 2weeks and 4weeks respectively. The efficacies of combination therapy and Hp clearance rates of two drugs in two weeks and four weeks were 89.4% , 87.7% and 100%, 93.0% respectively. The effective rate and Hp clearance rate of OME + GEN group at 2 and 4 weeks after treatment were significantly higher than those of GEN and OME group (P <0.01 and P <0.05) , 4 weeks treatment of DU efficiency and Hp clearance was significantly higher than the group GEN (P <0.01 and P <0.05), no obvious side effects. Conclusion The combination of OME and GEN in the treatment of Hp infection Du patients with high efficiency and Hp clearance rate, economical, safe and reliable, worthy of promotion of primary clinical applications.