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急性广泛前壁心肌梗塞较其他部位梗塞合并先兆性室性心律失常时,利多卡因(Lid)疗效明显降低(P<0.05).Lid对各类型的室性心律失常疗效无明显差异。Lid的用法,用量必须先给负荷量,继给维持量,于生效后24—48小时后停药。如仅给负荷量,或开始就用维持量均增加复发率,影响疗效。肌肉注射用Lid的负荷量值得推荐,因较静注安全而不影响疗效及生效时间,急性心肌梗塞(AMI)早期发生的较严重的室性早搏,有发生原发性心室颤动的先兆意义。对未合并室性心律失常的早期AMI病例,无必要普遍性用Lid预防心室颤动,只用于心电监测出室性心律失常的病例即可。
Acute extensive anterior myocardial infarction compared with other parts of the infarct complicated by threatened ventricular arrhythmias, the effect of lidocaine (Lid) was significantly reduced (P <0.05) .Lid no effect on various types of ventricular arrhythmias. Lid usage, the amount must be given to the load, following the maintenance volume, after taking effect after 24-48 hours withdrawal. If only to the load, or to maintain the amount of the beginning of the recurrence rate increase, affect the efficacy. The load of intramuscular injection of Lid is worth recommending. Because of the safety of intravenous injection without affecting the curative effect and effective time, the more severe premature ventricular contractions occur in acute myocardial infarction (AMI) in early stage, and the premonitory significance of occurrence of primary ventricular fibrillation. For patients with early AMI without ventricular arrhythmias, it is not necessary to use Lid to prevent ventricular fibrillation. It is only used for the cases of ventricular arrhythmia monitored by ECG.