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将３２例肛管和肛周尖锐湿疣进行Ａｐｇａｒ评分和凹空细胞分型，应用聚合酶链反应和免疫组化技术检测ＨＰＶ抗原和ＤＮＡ，并观察ＨＰＶ在尖锐湿疣组织中的分布状况。结果发现Ａ型１４例，Ｂ型１８例，Ａ型与高积分尖锐湿疣的关系较Ｂ型密切。ＰＣＲ和免疫组化检测阳性率分别为２５％（８／３２）和２２％（７／３２）。我们发现在尖锐湿疣组织中，不论是否是凹空细胞或凹空细胞分型如何及Ａｐｇａｒ积分高低，均有ＨＰＶ分布，但阳性率不同。这表明在正确诊断尖锐湿疣时，凹空细胞核形态、组织学改变和特殊检测三者各起作用并彼此相关。本文还探讨了浆膜型抗原发生机制。
32 cases of anal canal and perianal condyloma acuminatum were divided into Apgar score and empty cell cavity. HPV antigen and DNA were detected by polymerase chain reaction and immunohistochemistry, and the distribution of HPV in condyloma acuminatum was observed. The results showed that 14 cases of type A, 18 cases of type B, type A and high score condyloma acuminatum close than the B type. The positive rates of PCR and immunohistochemistry were 25% (8/32) and 22% (7/32) respectively. We found that in condyloma acuminatum, there are HPV distributions, regardless of the type of concave cells or concave cells and the Apgar score, but the positive rates are different. This indicates that concave nucleus morphology, histological changes, and special tests play a role in each other and correlate with each other in the correct diagnosis of condylomata acuminata. This article also explored the serosal antigen type of pathogenesis.