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目的:探讨慢性肾功能衰竭患者首次血液透析时贫血情况,并分析相关影响因素。方法:回顾性分析2014年1月1日至12月31日在暨南大学附属第一医院行首次血液透析的101例慢性肾功能衰竭患者的临床资料。以血红蛋白(Hb)为因变量,性别、年龄、肾病病史、肾内科就诊史、糖尿病史、感染史、红细胞生成刺激剂(ESA)使用史、估计肾小球滤过率(eGFR)、二氧化碳结合力(CO_2CP)、血清白蛋白(Alb)为自变量,进行多元线性回归分析。结果:患者平均Hb为(78±21)g/L。单因素分析结果显示,与Hb<90 g/L组相比,Hb≥90 g/L组中男性、肾内科就诊史及有ESA使用史的比例更高(P<0.05)。多元线性回归分析结果显示,影响贫血严重程度的因素包括肾内科就诊史、ESA使用史、eGFR和Alb水平(P<0.05)。结论:慢性肾衰竭患者首次血液透析时贫血严重,其严重程度与性别、肾内科就诊史、有ESA使用史、eGFR和Alb水平相关。
Objective: To investigate the anemia in hemodialysis patients with chronic renal failure and to analyze the related factors. Methods: The clinical data of 101 patients with chronic renal failure undergoing hemodialysis for the first time at the First Affiliated Hospital of Jinan University from January 1, 2014 to December 31, 2014 were retrospectively analyzed. Hb was used as a dependent variable, sex, age, history of nephropathy, history of nephrology visit, history of diabetes, history of infection, history of use of erythropoiesis-stimulating agent (ESA), estimated glomerular filtration rate (eGFR), carbon dioxide binding CO_2CP and Alb were independent variables for multiple linear regression analysis. Results: The mean Hb in patients was (78 ± 21) g / L. Univariate analysis showed that male and nephrologists had higher rates of history of treatment and history of ESA use (P <0.05) in the Hb ≥ 90 g / L group than in the Hb <90 g / L group. Multivariate linear regression analysis showed that the factors affecting the severity of anemia included history of nephrology, history of ESA use, eGFR and Alb (P <0.05). Conclusions: The first hemodialysis patients with chronic renal failure have severe anemia and their severity is related to sex, history of nephrology, history of ESA use, eGFR and Alb levels.