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本文改进了扑尔敏血药浓度的气相测定法。选用安定为内标,在异辛烷一次提取全血后用N~(63)电子捕获器检测。结果表明,在0.5～12ng/ml范围内,扑尔敏及安定的色谱峰面积之比(Ac/Ad)与血液中两者浓度之比(Cc Cd)有良好的线性关系(r=0.996),回收率在90％以上(平均偏差4％)。应用此法测定了人口服扑尔敏微丸及速释微丸的血药浓度,并由此计算得出控释微丸的体内吸收百分数(Pi)与体外溶出百分数(Po)间的相关方程式为Po=0.9597Pi+3.3225(r=0.916)
This article improves the concentration of chlorpheniramine gas phase determination. Diazepam was used as an internal standard, and once the whole blood of isooctane was extracted, it was detected by N 63 electron capture device. The results showed that there was a good linear relationship (r = 0.996) between the ratio of peak area of chlorpheniramine and diazepam (Ac / Ad) in the range of 0.5-12 ng / ml and the concentration of Cc Cd in blood , The recovery rate of more than 90% (average deviation of 4%). This method was used to determine the plasma concentrations of oral chlorpheniramine pellets and immediate release pellets and calculate the correlation equation between controlled release pellets in vivo absorption percentage (Pi) and in vitro dissolution percentage (Po) Po = 0.9597Pi + 3.3225 (r = 0.916)