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目的:探讨血清单核细胞趋化蛋白-1(monocyte chemoattractant protein-1,MCP-1)水平与冠心病的关系。方法:检索并筛检2010年12月31日前发表的MCP-1水平与冠心病关系的相关文献,利用Rev Man 4.2对各项研究结果进行异质性分析,选择适当的分析模型进行Meta分析。结果:共纳入13篇文献,稳定型心绞痛(stable angina,SA)396例、不稳定型心绞痛(un-stable angina,UA)366例、急性心肌梗死(acute myocardial infarction,AMI)268例及正常对照446例。Meta分析结果显示,SA、UA及AMI组患者血清MCP-1水平明显高于正常对照组(P均<0.01)。SA组标准化均数差(standardized mean difference,SMD)=0.71,95%可信区间(confidential interval,CI):0.30～1.12;UA组SMD=1.98,95%CI:1.15～2.81;AMI组SMD=2.69,95%CI:1.67～3.70;UA组患者血清MCP-1水平较SA组患者高0.77～2.20倍标准差,AMI组较UA组患者高0.32～0.67倍标准差。结论:冠心病患者血清MCP-1水平明显升高,且MCP-1水平与冠心病的严重程度相关。
Objective: To investigate the relationship between serum monocyte chemoattractant protein-1 (MCP-1) and coronary heart disease. Methods: The literature about the relationship between MCP-1 levels and coronary heart disease published before Dec. 31, 2010 was searched and screened. The heterogeneity of each study was analyzed by Rev Man 4.2, and the appropriate analysis model was selected for meta-analysis. Results: Thirteen articles were included. Among them, 396 cases of stable angina (SA), 366 cases of un-stable angina (UA), 268 cases of acute myocardial infarction (AMI) and normal controls 446 cases. Meta-analysis showed that serum MCP-1 levels in SA, UA and AMI groups were significantly higher than those in normal control group (all P <0.01). In the SA group, standardized mean difference (SMD) = 0.71, 95% confidence interval (confidential interval, CI): 0.30-1.12; SMD = 1.98, 95% CI: 1.15-2.81 in the UA group; SMD = 2.69, 95% CI: 1.67-3.70; serum MCP-1 level in patients with UA was 0.77 to 2.20 times of standard deviation higher than that of patients in SA group, and 0.32 to 0.67 times of standard deviation in AMI patients compared with those in UA patients. Conclusion: The serum level of MCP-1 in patients with coronary heart disease was significantly increased, and the level of MCP-1 was correlated with the severity of coronary heart disease.