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目的 探讨新生儿呼吸窘迫综合征 (RDS)予肺表面活性物质 (PS)治疗后的尿量变化及尿量与肺氧合功能的关系。方法 对新生儿重症监护病房 (NICU)行呼吸机治疗的 2 0例RDS患儿予血气监测及每小时尿量和入量监测。结果 观察组 (PS组 )最大尿量峰值出现于生后 6 0h ,与对照组比较有显著性差异 (P <0 0 5 )。尿量 /入量比值PS组于生后 48h即大于 0 8,而对照组的上述比值大于 0 8出现于生后 6 0h。尿量与动脉 /肺泡氧分压比值 (PaO2 /PAO2 )有显著相关性 (r =0 7414,P <0 0 5 )。结论 RDS病程中随着尿量增加肺氧合功能改善 ,予PS治疗后利尿期最大尿量峰值增大 ,出现时间早 ,提示在PS治疗后更应该密切观察尿量变化 ,判断病情的恢复。
Objective To investigate the changes of urine volume and the relationship between urine output and pulmonary oxygenation after newborn respiratory distress syndrome (RDS) is treated with pulmonary surfactant (PS). Methods Twenty patients with RDS undergoing ventilator treatment in neonatal intensive care unit (NICU) were given blood gas monitoring and hourly urine output and volume monitoring. Results The peak value of maximum urine volume in observation group (PS group) appeared at 60 h after birth, which was significantly different from that in control group (P <0.05). Urine volume / volume ratio of PS group at 48h after birth is greater than 0 8, while the ratio of the control group is greater than 0 8 occurs after 60h. There was a significant correlation between urine output and arterial / alveolar oxygen ratio (PaO2 / PAO2) (r = 0 7414, P <0 05). Conclusion During the course of RDS, the pulmonary oxygenation function was improved with the increase of urine volume. The peak of maximum urine output of diuresis increased after PS treatment and appeared earlier, suggesting that the changes of urine volume should be closely observed after PS treatment to determine the recovery of the disease.