论文部分内容阅读
目的观察曲安奈德联合雷公藤多甙片治疗口腔扁平苔癣(OLP)的临床疗效。方法 62例OLP患者,随机分为观察组和对照组,每组31例。两组均进行基础治疗,对照组应用曲安奈德联合利多卡因在口腔病损部位局部注射,观察组在对照组治疗的基础上加用雷公藤多甙片口服治疗,两组患者均治疗4周,观察两组近期临床疗效及6个月内复发率,并进行体征和疼痛VAS评分比较分析。结果治疗前,两组患者体征和疼痛VAS评分比较差异无统计学意义(P>0.05);治疗后,观察组患者体征评分为(0.91±0.11)分,VAS评分为(2.43±0.26)分,对照组患者体征评分为(2.43±0.25)分,VAS评分为(4.64±0.48)分,治疗后两组患者体征和疼痛VAS评分较治疗前均不同程度减低,且观察组患者体征和疼痛VAS评分降低显著优于对照组(P<0.05)。治疗1周后,观察组患者治疗总有效率为90.32%,对照组患者总有效率为67.74%,观察组患者治疗总有效率明显优于对照组,差异具有统计学意义(P<0.05)。治疗结束6个月后,观察组显效17例中有2例复发,复发率为11.76%,对照组显效14例中复发6例,复发率为42.86%,对照组复发率显著高于观察组,差异具有统计学意义(P<0.05)。结论曲安奈德联合雷公藤多甙片对OLP患者进行治疗,效果良好,值得临床推广应用。
Objective To observe the clinical efficacy of triamcinolone acetonide combined with tripterygium glycosides tablets in the treatment of oral lichen planus (OLP). Methods Sixty-two OLP patients were randomly divided into observation group and control group, with 31 cases in each group. The two groups were treated with basic triamcinolone acetonide combined with lidocaine in the oral lesion site injection, the observation group in the control group based on the treatment with the addition of tripterygium glycosides tablets oral treatment, two groups of patients were treated 4 Weeks, observe the two groups of recent clinical efficacy and recurrence within 6 months, and VAS scores were compared signs and pain. Results Before treatment, there was no significant difference in VAS score between the two groups (P> 0.05). After treatment, the score of the VAS score in the observation group was (0.91 ± 0.11) and the VAS score was (2.43 ± 0.26) The score of VAS in control group was (2.43 ± 0.25) points and VAS score was (4.64 ± 0.48) points. VAS score of signs and pains in both groups decreased to some degree after treatment, and VAS scores of signs and pain in observation group Reduce significantly better than the control group (P <0.05). After one week of treatment, the total effective rate was 90.32% in the observation group and 67.74% in the control group. The total effective rate of the observation group was significantly better than that of the control group (P <0.05). Six months after the end of treatment, 2 cases of recurrence were found in 17 cases, the recurrence rate was 11.76% in the observation group, 6 cases were recurrence in the 14 cases of the control group, the recurrence rate was 42.86%, the recurrence rate of the control group was significantly higher than that of the observation group, The difference was statistically significant (P <0.05). Conclusion Triamcinolone triptolide combined with Tripterygium tablets for OLP patients with treatment, the effect is good, worthy of clinical application.