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由于对严重烧伤伤员全身使用广谱抗生素和局部广泛应用抗菌药物,近年来播散性霉菌感染有增加的趋势,值得重视。本文所讨论的,也适用于其他病员中发生霉菌内脏感染的诊断与治疗。霉菌感染症状进展较慢,又不典型,往往与细菌感染并存而造成“二重感染”,这些因素极易造成漏诊和误诊,不少死亡病例经尸检后才得确诊。因此,国内外有关学者对霉菌感染给予较多的注意,临床上由于霉菌侵入局部及全身引起脓毒症的报导日见增多。如1971年Dennis氏分析一组病例,1953～1959年未发现霉菌性脓毒症,1959～1967年间则有27例,而1967～1970年间则达50例。1971年Nash分析美国Brooke中心在1960～1969年全部尸检病例的创面组织切片,发现在局部外用磺胺米隆(Sulfamelon)之前,仅在1/4创面上有霉菌,使用磺胺米隆后,增加了2倍;霉菌的深部感染增加了4倍;藻菌
Due to the widespread use of broad-spectrum antibiotics and the widespread application of antimicrobial agents to the severely burned wounded people, disseminated mold infections have shown an increasing trend in recent years and deserve attention. This article discusses, but also applies to other patients in the diagnosis and treatment of mold visceral infection. Mold infection symptoms progress slower, but not typical, often co-exist with bacterial infection and cause “double infection”, these factors can easily lead to missed diagnosis and misdiagnosis, many deaths confirmed by autopsy. Therefore, scholars at home and abroad give more attention to the fungal infection clinically due to mold invasion of local and systemic induced sepsis reported increasing. For example, Dennis’s analysis of a group of patients in 1971 did not reveal fungal sepsis from 1953 to 1959, 27 from 1959 to 1967, and 50 from 1967 to 1970. In 1971, Nash analyzed wound tissue sections of all autopsy cases from 1960 to 1969 at the Brooke Center in the United States and found that there was mold growth on only 1/4 of the wound surface prior to topical sulfamelon (Sulfamelon), with an increase of 2 times; mold infection 4 times deeper; algae bacteria