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多数肾脏疾病的发生、发展与免疫异常及炎症反应有关,糖皮质激素具有强大的抗炎和免疫抑制作用,是治疗肾病综合征、进展期肾病或病理有活动性病变的免疫介导性肾脏疾病的主要药物。但肾脏病应用激素治疗一般起始剂量大、疗程较长,使用不当会造成严重的不良反应。因此,应参照国内外关于肾脏病治疗的最新指南规范使用,严格掌握其适应证、疗效判断标准及影响因素,熟悉激素引起的副反应,坚持个体化治疗,避免盲目追求某些实验室指标(如蛋白尿)的减少而过度使用,在取得肾脏病临床缓解的同时尽可能减少不良反应。
Most of the occurrence and development of kidney disease and immune dysfunction and inflammatory response, glucocorticoid has a strong anti-inflammatory and immunosuppressive effects, is the treatment of nephrotic syndrome, advanced renal disease or pathological active lesions of immune-mediated kidney disease The main drug. However, the general application of hormonal nephropathy treatment of large initial dose, longer course of treatment, improper use can cause serious adverse reactions. Therefore, we should refer to the latest guidelines for the treatment of kidney disease at home and abroad regulate the use of strict control of their indications, efficacy criteria and the impact of factors that are familiar with side effects caused by hormones, adhere to individualized treatment, to avoid blind pursuit of some laboratory indicators Such as proteinuria) over the use of reduced, clinical remission in obtaining kidney disease while minimizing adverse reactions.