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肿瘤是多种基因突变的累积以及这些基因相互作用形成的基因网络调控的结果,目前RNA干扰技术越来越多地拓宽到肿瘤医学的研究领域。本文就RNA干扰技术在肿瘤基因治疗、在候选基因的发现和筛选中的应用以及临床研究进展方面做一综述。
Tumors are the accumulation of many kinds of gene mutations and the result of gene network regulation formed by the interaction of these genes. At present, RNA interference technology is more and more expanded to the field of oncology research. In this paper, RNA interference technology in cancer gene therapy, the discovery and selection of candidate genes in the application and clinical research advances are reviewed.