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目的:探究补肾活血法联合肼苯哒嗪对老年心力衰竭患者血清TNF-α、NF-κB、IL~(-1)β及临床疗效影响研究。方法:收集本院心血管内科收治的老年心力衰竭患者79例,根据随机对照表分为对照组和治疗组,两组均参照急慢性心力衰竭诊断和治疗指南实施常规基础以及对症治疗,对照组39例应用肼苯哒嗪治疗,治疗组40例在此基础上应用补肾活血汤,治疗结束后对比分析两组临床疗效、血清TNF-α、NF-κB、IL~(-1)β水平、不良反应。结果:治疗后,与对照组相比,治疗组患者的临床总有效率较高(P<0.05),血清TNF-α水平,NF-κB,IL~(-1)β水平较低(P<0.05),不良反应发生率较低(P<0.05)。结论:补肾活血法联合肼苯哒嗪在老年心力衰竭患者的治疗上降低血清TNF-α水平,调整机体内免疫功能,抑制炎症反应发生,降低氧需求;降低NF-κB水平,减少血管平滑肌细胞增殖;降低血清IL~(-1)β水平,抑制心肌纤维化,调整心脏泵功能。
Objective: To investigate the effects of Bushenhuoxue combined with hydralazine on serum TNF-α, NF-κB, IL-1β in elderly patients with heart failure and its clinical efficacy. Methods: A total of 79 elderly patients with heart failure admitted to our hospital were enrolled. According to the randomized control table, the patients were divided into control group and treatment group. Both groups were treated according to guidelines of diagnosis and treatment of acute and chronic heart failure, 39 cases were treated with hydralazine, and 40 cases in the treatment group were given Bushen Huoxue Decoction. After the treatment, the clinical curative effect, serum TNF-α, NF-κB and IL-1β levels, Adverse reactions. Results: Compared with the control group, the total effective rate of the treatment group was significantly higher (P <0.05), the levels of TNF-α, NF-κB and IL-1β were lower (P < 0.05), the incidence of adverse reactions was lower (P <0.05). Conclusion: Bushenhuoxue combined with hydralazine can reduce the level of serum TNF-αin the elderly patients with heart failure, regulate the immune function, inhibit the inflammatory reaction and reduce the oxygen demand, reduce the level of NF-κB and decrease the level of vascular smooth muscle cells Proliferation, decrease the serum level of IL-1, inhibit myocardial fibrosis and regulate cardiac pump function.