论文部分内容阅读
肾素-血管紧张素-醛固酮系统与血管紧张力的调节密切相关,而且对钠的内环境稳定具有重要作用。八肽血管紧张素Ⅱ系转化酶对无活性的前体十肽血管紧张素Ⅰ的作用下而形成。血管紧张素Ⅱ收缩小动脉,增强交感神经的活性,促进钠潴留;这些都是通过肾的直接作用或是通过醛固酮的释放而产生的。高血压和心力衰竭是以增强外周血管张力以及钠和水排泄异常为特征的,但是这些变化在多大程度上反映出肾素-血管紧张素-醛固酮系统的活性尚不清楚。利尿剂和血管舒张剂即
The renin-angiotensin-aldosterone system is closely related to the regulation of vascular tone and plays an important role in the stabilization of sodium homeostasis. The octapeptide angiotensin II converting enzyme is formed by the action of an inactive precursor decapeptide, angiotensin I. Angiotensin II contracts the arterioles, enhances sympathetic activity, and promotes sodium retention; these are produced either directly through the kidneys or through the release of aldosterone. Hypertension and heart failure are characterized by increased peripheral vascular tone and abnormal sodium and water excretion, but to what extent these changes reflect the activity of the renin-angiotensin-aldosterone system is unclear. Diuretics and vasodilators ie