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本文报道高血糖素对一例心得平过量的效用。患者男性、62岁,因虚脱于1975年6月入院。在救护车中曾作心脏按摩,到达医院时脉搏已消失,四肢发冷、发紫。瞳孔直径4毫米,对光反应消失。心电图检查示心收缩不全。经静注异丙肾上腺素、1/1000肾上腺素3毫升、葡萄糖酸钙20毫升及碳酸氢钠100毫升,35分钟后出现缓慢窦性心律,心率32次/分。再静注阿托品0.6毫克后,增至68次/分。随之呼吸恢复,瞳孔缩小至3毫米,并有对光反应。但收缩压仍在30毫米汞柱以下。虽再持续滴注肾上腺素1个多小时,心率和血压仍无变化。于是静注高血糖素10毫克,一分钟内血压即上升至150毫米汞柱。不久周围循环改善。但随着心血管情况好转却出现严重支气管痉挛,经静注间羟叔丁肾上腺素后缓解。尿量由30毫升/小时增至150毫升/小时。中心静脉压由15厘米水柱下降
This article reports the effect of glucagon on an overactive condition. Male patient, aged 62, was admitted to hospital in June 1975 for collapse. Had a heart massage in the ambulance, arrived at the hospital pulse has disappeared, limbs cold, purple. Pupil diameter of 4 mm, the response to light disappeared. ECG showed cardiac insufficiency. After intravenous isoproterenol, 1/1000 epinephrine 3 ml, calcium gluconate 20 ml and sodium bicarbonate 100 ml, 35 minutes after the emergence of slow sinus rhythm, heart rate 32 beats / min. And then intravenous injection of atropine 0.6 mg, increased to 68 beats / min. Respiratory resuscitation, pupil shrink to 3 mm, and there is light response. But systolic blood pressure is still below 30 mm Hg. Although continued infusion of epinephrine more than 1 hour, heart rate and blood pressure remained unchanged. So intravenous glucagon 10 mg, one minute blood pressure rose to 150 mmHg. Soon around the cycle to improve. However, with the improvement of cardiovascular conditions, severe bronchospasm occurred and was relieved after intravenous injection of hydroxy-tert-butanalpine. Urine increased from 30 ml / hour to 150 ml / hour. Central venous pressure decreased by 15 cm water column