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目的研究分析米非司酮配伍依沙吖啶终止瘢痕子宫中期妊娠的临床效果,为临床提供依据。方法选取本院2010年5月~2013年6月收治的50例按照自愿要求终止中期妊娠瘢痕子宫患者,按照自愿选择治疗原则随机平均分为对照组和观察组各25例,对照组经腹羊膜腔内注入依沙吖啶,观察组在对照组的基础上,随后口服米非司酮,观察两组患者的临床效果、引产成功率和出现的不良反应。结果服药后观察组临床效果观察指标(宫颈成熟情况、宫缩发动时间、引产时间、引产出血量、住院时间)均明显高于对照组,两组比较差异具有统计学意义(P<0.05);采用两药合用引产成功率较高,完全引产,对照组引产失败5例;两组发生不良反应不明显,无需做特殊处理。结论米非司酮配伍依沙吖啶应用瘢痕子宫中期妊娠引产能缩短引产时间,安全有效,提高引产成功率,减少不良反应,值得在临床上进一步推广应用。
Objective To study the clinical efficacy of mifepristone in combination with ethacridine to terminate scar pregnancy in the second trimester of pregnancy and provide evidence for its clinical application. Methods From May 2010 to June 2013 in our hospital, 50 cases of patients with uterine scar were randomly divided into control group and observation group according to the principle of voluntary choice. The control group received transabdominal amnion Intracaval injection of ethacridine, the observation group on the basis of the control group, followed by oral mifepristone, the clinical efficacy of two groups were observed, the success rate of induced labor and the emergence of adverse reactions. Results After treatment, the clinical observation results (cervical maturation, uterine contractions time, induction of labor, induction of labor and hospital stay) were significantly higher in the observation group than those in the control group. There was significant difference between the two groups (P <0.05). The combination of two drugs with high success rate of induction, complete induction of labor, control group failed induction of labor in 5 cases; adverse reactions were not obvious in both groups, without special treatment. Conclusion The combination of mifepristone and ethacridine can shorten the time of induction of labor during the second trimester of pregnancy. It is safe and effective to improve the success rate of induced labor and reduce the adverse reactions. It is worth further clinical application.