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目的观察辛伐他汀对高胆固醇血症患者血管内皮功能的影响。方法选择高胆固醇血症 (HC) 3 1例 ,口服辛伐他汀 ,分别于治疗前、后进行血管内皮素 (ET)及血脂测定 ;另选 3 0例健康体检者对照。结果辛伐他汀治疗 8周 ,血 TC,低密度脂蛋白 -胆固醇 (LDL -C)明显下降 (P<0 .0 1) ,血浆内皮素由治疗前的 (83 .3 7± 2 6.45 ) pg/ml降至 (5 2 .5 7± 12 .64 ) pg/ml(P<0 .0 1)。结论辛伐他汀在显著降低 HC与 LDL -C的同时 ,能改善血管内皮细胞功能。
Objective To observe the effect of simvastatin on vascular endothelial function in patients with hypercholesterolemia. Methods Eleven patients with hypercholesterolemia (HC) were selected and received simvastatin orally. Endothelin (ET) and serum lipids were measured before and after treatment. Another 30 healthy controls were selected. Results After simvastatin treatment for 8 weeks, blood TC and LDL-C levels were significantly decreased (P <0.01), and plasma endothelin levels were significantly decreased from 83.7 ± 2.64 pg / ml to (52.57 ± 12.64) pg / ml (P <0.01). Conclusion Simvastatin can significantly improve the function of vascular endothelial cells while significantly reducing HC and LDL-C.