Oncogene:阻断癌细胞对低氧应答遏制最难治乳腺癌

• 出 处: 现代生物医学进展
• 发表日期: 2016年23期
• 关键词: 乳腺癌 低氧 癌细胞 Oncogene 乳腺肿瘤 诺丁汉 国际学术期刊 血管生成 乳腺癌细胞 恶性乳腺肿瘤

英国科学家最近发现一种延缓乳腺癌生长的新方法,相关研究结果发表在国际学术期刊Oncogene上。来自牛津大学和诺丁汉姆大学的研究人员发现使用一种叫做JQ1的药物能够改变癌细胞对低氧产生的应答反应,在许多乳腺肿瘤中都存在低氧情况,特别是最难以治疗的三阴性乳腺癌。研究发现JQ1通过阻止癌细胞对低氧产生的适应性变化发挥作用,JQ1能够延缓肿瘤生长并限制血管生成。

British scientists recently discovered a new way to delay the growth of breast cancer, the relevant research results published in the international academic journal Oncogene. Researchers from the University of Oxford and the University of Nottingham found that using a drug called JQ1 alters the response of cancer cells to hypoxia and hypoxia in many breast tumors, especially the most intractable triple negative cancer. The study found that JQ1 acts by retarding adaptive changes in cancer cells to hypoxia, which slows tumor growth and limits angiogenesis.