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目的探讨凝血4项和血小板参数指标在肝硬化患者病情中的变化及意义。方法对65例肝硬化患者与40例健康对照组进行凝血4项凝血活酶时间(TT)、凝血酶原时间(PT)、纤维蛋白原(FIB)、活化部分凝血活酶时间(APTT)和血小板参数血小板计数(PLT)、血小板平均体积(MPV)、血小板压积(PCT)、血小板分布宽度(PDW)指标检测。结果 PT、APTT、FIB、PLT、PCT、MPV、PDW8项指标中,PT、APTT明显延长,TT稍延长,FIB、PLT、PCT显著减少,MPV、PDW增大均有统计学意义(P<0.01),且异常程度与肝硬化的严重程度相关。结论凝血4项和血小板参数联合检验,对观察肝硬化患者肝脏功能损害程度、判断预后及指导临床用药具有重要的临床意义。
Objective To investigate the changes and significance of 4 coagulation parameters and platelet parameters in patients with cirrhosis. Methods Thrombolytic time (TT), prothrombin time (PT), fibrinogen (FIB) and activated partial thromboplastin time (APTT) were measured in 65 patients with cirrhosis and 40 healthy controls. Platelet count (PLT), mean platelet volume (MPV), platelet pressure (PCT) and platelet distribution width (PDW) were measured. Results In PT, APTT, FIB, PLT, PCT, MPV and PDW8 indicators, PT, APTT were significantly prolonged, TT was slightly prolonged, FIB, PLT and PCT were significantly decreased, MPV and PDW were significantly increased ), And the degree of abnormality is related to the severity of cirrhosis. Conclusion Coagulation combined with platelet parameters 4, the observation of liver cirrhosis patients with functional impairment, prognosis and guide the clinical use of drugs has important clinical significance.