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动物测痛模型一般基于动物对疼痛刺激的行为反应,试验多靠实验者的主观评定,因而总是给研究者带来问题。近年来作者在大鼠毒理研究中发展了一种能够客观地、定量地评价静脉给药致痛反应的筛选程序,可望在新药研制早期检出化合物或溶剂的这种不良反应。测痛反应在加装有应变计的制动管中进行,其原理是疼痛引起挣扎使管变形,从而使应变电桥输出电压产生变化,经模数转换输入微机,最后将数据变换为对数并进行方差分析。实验前先将聚乙烯导管插入大鼠侧尾静脉,2h后将动物放进管中适应3min,接着静
Animal pain models are generally based on behavioral responses of animals to painful stimuli and are often subjectively assessed by experimenters and therefore always pose a problem to researchers. In recent years, the authors developed a screening program that can objectively and quantitatively evaluate the analgesic effect of intravenous administration in rat toxicology research and is expected to detect such adverse reactions of compounds or solvents early in the development of new drugs. Analgesic reaction in the installation of a strain gauge brake tube, the principle is the pain caused the tube deformation, so that the strain bridge output voltage changes, the analog-digital conversion input microcomputer, and finally the data is converted to the right Number and analysis of variance. Before the experiment, the polyethylene catheter was inserted into the tail vein of the rat, and after 2 hours, the animals were put in the tube and adapted for 3 minutes, followed by static