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介绍两种测定西咪替丁的方法,即西咪替丁在它的酸裂解产物存在时用UV法(方法Ⅰ)测定第二衍生物和应用2,6-二氯苯酚-靛酚比色法(方法Ⅱ)测定。两种方法的相对标准偏差分别为0.75%和0.72%。两种方法测定西咪替丁片剂的平均标准偏差各为100.5±0.68%和100.1±0.92%。测定安瓿时的平均标准偏差各为99.5±0.77%和100.1±0.79%。标准溶液1.西咪替丁200μg/ml(标准A)准确称20mg西咪替丁,用20ml0.1mol/L盐酸
Two methods for the determination of cimetidine are described, namely the cimetidine determination of the second derivative by the UV method (method I) in the presence of its acid cleavage product and the application of 2,6-dichlorophenol-indophenol colorimetric Method (Method Ⅱ) Determination. The relative standard deviations of the two methods were 0.75% and 0.72%, respectively. The mean standard deviations of the two methods for the determination of cimetidine tablets were 100.5 ± 0.68% and 100.1 ± 0.92%, respectively. The mean standard deviations for the determination of ampules were 99.5 ± 0.77% and 100.1 ± 0.79%, respectively. Standard solution 1. Cimetidine 200μg / ml (standard A) Accurately weighed 20mg cimetidine, with 20ml0.1mol / L hydrochloric acid