论文部分内容阅读
目的:分析新生儿不同病原菌化脓性脑膜炎的临床特点及预后因素。方法:回顾性分析本院2013年1月~2017年1月收治的100例新生儿化脓性脑膜炎患儿的相关资料,比较不同病原菌化脓性脑膜炎脑脊液检查结果、白细胞计数、发热持续时间等指标及预后情况,并通过多元线性逐步回归分析影响患儿预后的相关因素。结果:大肠埃希菌组脑脊液浑浊及脓性率均显著高于其他细菌组、病原菌不明组(66.67%vs.20.83%、16.39%,26.67%vs.4.17%、4.92%;大肠埃希菌组白细胞计数、发热持续时间、脑脊液恢复时间、住院时间均显著大于,脑脊液糖水平显著低于及预后不良率显著高于其他细菌组、病原菌不明组;多元线性逐步回归分析显示影响新生儿化脓性脑膜炎预后不良的独立危险因素为白细胞计数>500×106/L。结论:大肠埃希菌感染患儿脑脊液以浑浊、脓性为主,白细胞计数水平显著高,预后差;脑脊液糖浓度低、白细胞计数高是新生儿化脓性脑膜炎预后不良独立危险因子。
Objective: To analyze the clinical features and prognostic factors of purulent meningitis in neonates with different pathogens. Methods: The clinical data of 100 neonates with purulent meningitis in our hospital from January 2013 to January 2017 were retrospectively analyzed. The cerebrospinal fluid test results, white blood cell count, duration of fever, etc. of different pathogenic purulent meningitis were compared Indicators and prognosis, and through multiple linear regression analysis of prognostic factors in children. Results: The turbidity and purulent rate of CSF in Escherichia coli group were significantly higher than those in other bacterial groups (66.67% vs.20.83%, 16.39%, 26.67% vs.4.17%, 4.92%, Escherichia coli group White blood cell count, duration of fever, recovery time of cerebrospinal fluid and hospital stay were significantly greater than those of cerebrospinal fluid glucose levels were significantly lower and poor prognosis than other bacterial groups, pathogen unknown group; multivariate linear stepwise regression analysis showed neonatal purulent meningitis The independent risk factor for poor prognosis was white blood cell count> 500 × 106 / L. Conclusion: Cerebrospinal fluid in children with Escherichia coli infection is mainly turbid and purulent, with high leukocyte count and poor prognosis; low cerebrospinal fluid glucose concentration, High count is neonatal purulent meningitis poor prognosis independent risk factors.