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目的观察都安县艾滋病(AIDS)病人抗病毒治疗的临床疗效、不良反应及全血CD4淋巴细胞水平的变化。方法对近两年来县人民医院收治的109例艾滋病病毒感染者/艾滋病病人(HIV/AIDS病人),采用高效抗反转录病毒治疗(HAART)3个月后,观察其体重、机会性感染控制情况、生存状况和生活质量改善情况、不良反应及全血CD4水平的变化。结果 109例病人中,78例病人治疗前体重下降,治疗后所有病人体重上升,治疗前后体重变化差异有统计学意义(P<0.001)。81例合并机会性感染的病人病情得到明显控制,治疗前不能从事体力劳动,治疗后有69例恢复了劳动能力;58例病人出现不良反应,经更换方案或对症处理后不良反应消失;104例病人全血CD4水平上升,治疗前后CD4对比差异有统计学意义(P<0.001)。结论 HAART治疗HIV/AIDS病人临床疗效良好;有一定的不良反应,经对症处理后不良反应消失;能提高病人全血CD4的水平。
Objective To observe the clinical efficacy, adverse reactions and changes of whole blood CD4 lymphocyte level in antivirus treatment of AIDS patients in Du’an County. Methods A total of 109 HIV / AIDS patients (HIV / AIDS patients) admitted to County People’s Hospital in the recent two years were enrolled in this study. After 3 months of HAART treatment, their weight and opportunistic infections Status, quality of life and quality of life, adverse reactions and changes in CD4 levels in whole blood. Results Among the 109 patients, 78 patients lost weight before treatment. All patients gained weight after treatment. There was significant difference in body weight before and after treatment (P <0.001). Eighty-one patients with opportunistic infections were significantly controlled and were unable to engage in manual labor prior to treatment. Sixty-nine patients recovered their ability to work after treatment. Fifty-eight patients developed adverse reactions and the adverse reactions disappeared after replacement or symptomatic treatment. Another 104 Patient CD4 blood CD4 level increased before and after treatment, CD4 difference was statistically significant (P <0.001). Conclusion HAART treatment of HIV / AIDS patients with good clinical efficacy; there are some adverse reactions, the adverse reactions disappeared after symptomatic treatment; can increase the level of CD4 in patients with whole blood.