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利用PEO137-b-PPO44-b-PEO137三嵌段聚合物促进碳纳米管在溶液中的分散,进而制备出碳纳米管复合海藻酸微球药物载体.碳纳米管的引入对海藻酸微球的结构与形态无明显影响,但有效地提高了其稳定性,药物包封率从76.5%提高到89.2%.进一步研究发现碳纳米管复合海藻酸微球的溶胀行为和药物释放行为继承了海藻酸的pH敏感性,在胃pH 1.0环境中溶胀度仅为约76%,而在肠和结肠pH环境中溶胀度可达到2 000%以上甚至溶蚀,适合于用作肠和结肠中的药物控制释放.同时,碳纳米管的引入能够有效地降低药物的释放速率,提高缓释效果,而且不会额外地增加载体的细胞毒性.
The use of PEO137-b-PPO44-b-PEO137 triblock polymer to promote the dispersion of carbon nanotubes in solution, and then prepared carbon nanotubes composite alginate microspheres drug carrier. The introduction of carbon nanotubes on the alginate microspheres Structure and morphology, but its stability was improved effectively.The drug entrapment efficiency increased from 76.5% to 89.2% .Further study found that the swelling behavior and drug release behavior of the composite nano-Alginate microspheres inherited alginic acid PH-sensitive, has a degree of swelling of only about 76% in a pH of 1.0 of the stomach and a swelling of more than 2000% or even dissolution in the pH environment of the intestine and colon, and is suitable for use as a drug-controlled release in the intestine and colon At the same time, the introduction of carbon nanotubes can effectively reduce the drug release rate, improve the sustained release effect, and does not additionally increase the carrier cytotoxicity.