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姊妹染色单体交换(SCE)是染色体损伤的很敏感的指标。很多诱变剂能在低于引起染色体畸变的剂量下使SCE 明显增加。很多化学物质和一些物理因素,以及吸烟、饮酒和种痘等均能使SCE 增高。细胞周期持续时间亦可影响SCE 频率;能够变更细胞周期的物理、化学因素(某些致癌剂或高浓度的BrdU)可导致SCE 频率改变。但这些改变可能与它们对遗传物质本身的作用无关,而与细胞周期长度变更有关。本研究旨在获得有关温度变化与人体淋巴细胞周期的关系,
Sister chromatid exchange (SCE) is a very sensitive indicator of chromosomal damage. Many mutagens can significantly increase SCE at doses below chromosomal aberrations. A lot of chemicals and some physical factors, as well as smoking, drinking and vaccination can make SCE increased. The duration of the cell cycle also affects the frequency of SCEs; the physical and chemical factors that alter the cell cycle (certain carcinogens or high concentrations of BrdU) can lead to changes in the frequency of SCE. However, these changes may not be related to their role in the genetic material itself, but to changes in the length of the cell cycle. This study aims to obtain the relationship between temperature changes and the human lymphocyte cycle,