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目的:研究雷公藤多苷片联合低分子肝素治疗小儿紫癜性肾炎的临床疗效及免疫调节机制。方法:选取我院儿科收治的70例患儿,随机分为对照组34例和研究组36例。对照组给予常规处理措施联合雷公藤多苷片口服治疗,研究组在对照组基础上给予静脉输注低分子肝素钙治疗,比较两组患儿临床疗效及治疗前、治疗12周后免疫指标变化情况。结果:研究组、对照组治疗总有效率为88.9%及67.6%,两组比较差异有统计学意义(χ2=4.69,P<0.05)。研究组治疗12周后IL-6、IL-18、TNF-α水平分别为(19.3±2.6)pg/m L、(37.9±7.6)pg/m L、(2.5±0.9)pg/m L,均较对照组明显下降(P<0.05);IL-10水平为(76.3±22.7)pg/m L,较对照组明显升高(P<0.05)。结论:雷公藤多苷片联合低分子肝素钙治疗小儿紫癜性肾炎临床效果较满意,可有效改善其免疫炎症指标,具有较高的临床推广价值。
Objective: To study the clinical efficacy and immunoregulation mechanism of Tripterygium wilfordii glycosides combined with low molecular weight heparin in the treatment of purpura nephritis in children. Methods: A total of 70 children admitted to our hospital were randomly divided into control group (34 cases) and study group (36 cases). The control group was given routine treatment combined with oral administration of Tripterygium tablets, the study group was given intravenous infusion of low molecular weight heparin calcium on the basis of the control group. The clinical efficacy and the change of immune indexes Happening. Results: The total effective rates of the study group and the control group were 88.9% and 67.6%, respectively. There was significant difference between the two groups (χ2 = 4.69, P <0.05). The levels of IL-6, IL-18 and TNF-α in the study group after 12 weeks of treatment were (19.3 ± 2.6) pg / m L, 37.9 ± 7.6 pg / m L and 2.5 ± 0.9 pg / (P <0.05). IL-10 level was (76.3 ± 22.7) pg / m L, which was significantly higher than that of the control group (P <0.05). Conclusion: Tripterygium wilfordii tablets combined with low molecular weight heparin calcium in the treatment of children with purpuric nephritis clinical effect is satisfactory, which can effectively improve the immune inflammation, has a high clinical value.