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目的探讨乳腺癌组织中survivin、增殖细胞核抗原(PCNA)、Bcl-2的表达及其与临床病理因素的关系。方法采用免疫组化法检测64例乳腺癌标本中survivin、PCNA、Bcl-2的表达,并分析其与临床病理因素的关系。结果survivin和Bcl-2表达阳性率分别为71.87%和62.5%,且淋巴结转移组survivin表达阳性率高于无淋巴结转移组,差异有统计学意义(P<0.05)。PCNA指数(PI)平均为(61.5±10.1)%,并与淋巴结有无转移、肿块大小、临床TNM分期、组织学分级、survivin表达相关(P<0.05)。结论乳腺癌患者survivin与Bcl-2的表达不相关,有各自不同的机制;PCNA促进肿瘤细胞增殖和进展。
Objective To investigate the expression of survivin, proliferating cell nuclear antigen (PCNA) and Bcl-2 in breast cancer and its relationship with clinicopathological factors. Methods The expressions of survivin, PCNA and Bcl-2 in 64 cases of breast cancer specimens were detected by immunohistochemistry and their relationship with clinicopathological factors were analyzed. Results The positive rate of survivin and Bcl-2 expression was 71.87% and 62.5% respectively, and the positive rate of survivin in lymph node metastasis group was higher than that in non-lymph node metastasis group (P <0.05). The average PCNA index (PI) was (61.5 ± 10.1)% and correlated with lymph node metastasis, tumor size, TNM staging, histological grade and survivin expression (P <0.05). Conclusion There is no correlation between the expression of survivin and Bcl-2 in breast cancer patients. Different mechanisms exist in the expression of survivin. PCNA can promote the proliferation and progression of tumor cells.