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为建立闭合性脑硬膜外占位性颅脑损伤的大鼠模型,利用5F 漂浮导管置脑硬膜外模拟占位,按球囊注入水量和持续时间分组。观察各组动物的死亡率,存活鼠的颅内压、脑含水量的变化以及血肿形成、组织受损的情况。结果显示:球囊越大,持续时间越长,损伤越大;存活鼠颅内压及脑水含量均增加,神经机能受损,并有血肿形成和受压区坏死;上述变化随占位时间延长和受压程度的加重而加重。提示该脑损伤模型简单可行、可重复,能较好地反映硬膜外占位性脑损伤的病理分级,且经济实用
In order to establish a rat model of closed brain injury caused by epidural trauma, the 5F floating catheter was used to simulate the epidural space and then grouped according to the volume and duration of balloon infusion. The mortality rate of each group of animals, intracranial pressure in surviving rats, changes in brain water content, hematoma formation and tissue damage were observed. The results showed that: the larger the balloon, the longer the duration of injury, the greater the damage; the survival of intracranial pressure and brain water content were increased, impaired neurological function, with hematoma formation and compression zone necrosis; these changes with time Exacerbated and the degree of compression worsened. It is suggested that this model of brain injury is simple and feasible and reproducible, which can well reflect the pathological grading of epidural space-occupying brain injury and is economical and practical