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T_3一次注射后半小时或离体给予,小鼠脑内cAMP含量均未见变化,T_3连续注射三天脑内cAMP含量明显升高;T_3整体或离体给予,均使脑内cGMP含量迅速下降,表明T_3对cAMP的影响为延迟效应,对cGMP则为直接、快速作用。T_3连续注射三天,脑内高亲和力cAMP-PDE活性下降,表明T_3所致cAMP改变与该酶活性变化有关。T_3连续注射后并用Ad,脑内cAMP含量比单用Ad时高30％,cAMP-PDE活性下降程度亦比单用T_3连续注射者更显著,表明该酶活性下降可能是T_3增强脑对Ad敏感性的原因之一。
T_3 a half hour after injection or ex vivo administration, cAMP content in mouse brain showed no change, T_3 three days after continuous injection of cAMP content was significantly increased brain; T_3 total or ex vivo administration, the brain cGMP content decreased rapidly , Indicating that the effect of T_3 on cAMP is a delay effect and a direct and rapid effect on cGMP. T_3 injection for three days, brain high affinity cAMP-PDE activity decreased, indicating that T_3 cAMP changes caused by changes in the activity of the enzyme. After continuous injection of T_3 and Ad, the content of cAMP in the brain was 30% higher than that of Ad alone, and the decrease of cAMP-PDE activity was more significant than that of continuous injection of T_3 alone. One of the reasons for sex.