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甲状腺病、糖尿病、恶性贫血及伴随Addison病的自身免疫肾上腺炎患者有异常高的白癜风发生率.白癜风患者血清内常有一种同甲状腺及胃的器官特异性自身抗原反应的抗体,少数患者血清内有一种同表皮黑素细胞反应的抗体.这些发现及损害的组织学变化提示,至少某些患者是属于器官特异性自身免疫疾病.作为此类疾病研究,作者发现某些患者皮损解剖分布同典型的自身免疫及风湿病的内脏损害解剖分布类似.
Thyroid disease, diabetes mellitus, pernicious anemia and autoimmune adrenitis with Addison disease have a very high incidence of vitiligo. Vitiligo patients often have a serum with the thyroid and stomach organ-specific autoantigen antibodies, a small number of patients within the serum There is an antibody that reacts with epidermal melanocytes.These histopathological changes indicate that at least some of the patients are organ-specific autoimmune diseases.As a study of such diseases, the authors found that the anatomical distribution of lesions in some patients was the same Anatomical distributions of the typical autoimmune and rheumatic visceral lesions are similar.