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近几年,临床应用黄连素静脉滴注治疗慢性、迁延性肝炎、急性肠胃炎、菌痢等肠道感染获得一定疗效。同时亦见肌注黄连素引起过敏反应和静滴较大剂量黄连素发生严重急性心源性脑缺氧综合征的报道。但小剂量黄连素静滴引起过敏尚属少见,为引起医务工作者的重视,现将1978年我院在治疗1例慢性结肠炎患者时用黄连素静滴所致过敏反应摘要报告如下: 傅××,男,35岁,农民。于1978年11月25日以慢性结肠炎住院。11月27日开始肌注黄连素4毫克,每日2次。12月2日加用黄连素20毫克、氢化可的松100毫克、0.5％普鲁卡因80毫升保留灌肠,每晚1次。以上所用黄连素均系广州第二制药厂生产,未见不良反应。12月10日因医院无药暂停,至12月13日患者从开封印刷厂医务室取黄连素8支(16毫克),系江苏徐州制药厂生产,批号770519·1。
In recent years, clinical application of berberine intravenous infusion of chronic, chronic hepatitis, acute gastroenteritis, dysentery and other intestinal infections have a certain effect. Also see intramuscular injection of berberine cause allergic reactions and intravenous infusion of larger doses of berberine serious acute cardio-cerebral ischemia syndrome reported. However, small doses of berberine intravenous infusion of allergy is still rare, in order to attract medical attention, now in 1978 in our hospital in the treatment of 1 patients with chronic colitis with berberine intravenous infusion of allergic reactions summary report is as follows: Fu × ×, male, 35 years old, farmer. On November 25, 1978 with chronic colitis hospitalized. November 27 intramuscular injection of berberine 4 mg, 2 times a day. December 2 plus berberine 20 mg, hydrocortisone 100 mg, 0.5% procaine 80 ml retention enema, 1 night. The above used berberine are the second Guangzhou Pharmaceutical Factory production, no adverse reactions. On December 10, the hospital suspended 8 pills (16 mg) of berberine from the medical office of Kaifeng Printing Factory to Dec. 13, which was produced by Xuzhou Pharmaceutical Factory in Jiangsu Province with a batch number of 770519.1.