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葡萄球菌A蛋白(SPA)是大多数葡萄球菌细胞壁的一种成分。它对多种哺乳动物的免疫球蛋白IgG有很强的亲和性,因而可作为一种抗-IgG的免疫学试剂。近年来,已有许多获得成功的报导。尤其是70年代后期,关于用A蛋白纯品结合一些标记物的许多报导表明,在各种免疫学试验中,用SPA比早先直接使用葡萄球菌优越得多,其敏感性和准确性得到了进一步提高。本文扼要介绍了近年来关于葡萄球菌A蛋白的性质以及在标记抗体免疫鉴定试验中应用的进展概况。葡萄球菌A蛋白的主要特性许多金黄色葡萄球菌的细胞壁中皆含有
Staphylococcal protein A (SPA) is a component of most staphylococcal cell walls. It has a variety of mammalian immunoglobulin IgG has a strong affinity, and therefore can be used as an anti-IgG immunological reagents. In recent years, there have been many successful reports. In the late 1970s, in particular, many reports on the use of pure A-protein in combination with some markers showed that the use of SPA was significantly superior to the earlier direct use of staphylococci in various immunological tests with further improvements in sensitivity and accuracy improve. This article briefly introduced the recent years about the nature of Staphylococcal protein A and the application of the labeled antibody immunoassay in the progress of the application of the survey. Staphylococcal protein A main features Many Staphylococcus aureus cell walls are contained