T-2毒素的溶血毒性

• 作 者: 黄杰
• 出 处: 国外医学(卫生学分册)
• 发表日期: 1985年02期
• 关键词: 毒素 红细胞溶血 形态学改变 外周循环 血红细胞 体外试验 中毒症 T-2 实验条件 细胞毒性

T-2毒素是分布比较广泛的12、13-环氧单端孢霉烯类之一。许多报道指出T-2毒素与遍及全世界的人、畜及家禽的真菌毒素中毒症爆发有关。实验条件下,T-2毒素可引起猫、小鼠、豚鼠和鸡外周循环血红细胞、白细胞减少及形态学改变,体外试验可抑制蛋白质和DNA合成。本文作者用溶血作为细胞毒性的一种表现,研究了T-2毒素引起红细胞溶血的毒作用机制。

T-2 toxin is one of the more widely distributed 12,13-epoxy trichothecenes. Many reports point out that T-2 toxin is associated with mycotoxins outbreaks in humans, livestock and poultry throughout the world. Under the experimental conditions, T-2 toxin can cause circulating red blood cells, leukopenia and morphological changes in cats, mice, guinea pigs and chickens. In vitro experiments can inhibit protein and DNA synthesis. The authors use hemolysis as a manifestation of cytotoxicity to study the toxic mechanism of T-2 toxin-induced hemolysis of erythrocytes.