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近年来帕金森氏病(PD)的研究有了重要进展。鉴定了致病因素,药理学上引入了新的概念和技术,采用了新的观点,解决了治疗中的问题。对 PD 的原因从多方面进行了研究,PD 双胎符合率极低,因而引起对成人期环境中危险因素的重视。Langston 等指出一种诱发严重和长期帕金森氏征的强烈毒性物质,可因偶然接触进入脑部。第一类这种物质是1—甲基—4苯基—1.2、5、6—四氢吡啶(MPTP)可能还有多种。Burns 等提示 MPTP 使恒河猴患帕金森征且能被抗帕金森征药物控制,并指出 PD的黑质致密带细胞首当其冲出现仅一种高选择性的多巴胺能神经元死亡。在鼠猴也复制出了类似损害。因黑质极易随正常衰老过程而损害,有人推测 PD 可能是亚临床接触了毒素随后导致了与年龄有关的神
In recent years, Parkinson’s disease (PD) research has made important progress. Identified the causative agents, pharmacologically introduced new concepts and techniques, adopted a new point of view, to solve the problem of treatment. The reasons for PD are studied in many ways. The coincidence rate of PD twins is very low, which causes the attention to the risk factors in adulthood. Langston et al. Pointed out that a very toxic substance that induces signs of severe and long-term Parkinson’s may come into contact with the brain by chance. The first class of this substance is 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) There may be a variety of. Burns et al. Suggested that MPTP causes Parkinson’s sign in rhesus monkeys and is controlled by anti-Parkinson’s disease drugs. It also points out that PD substantia nigra stromal cells take the lead only to death of one highly selective dopaminergic neuron. A similar damage was also replicated in the rodent monkey. Since the substantia nigra is extremely vulnerable to normal aging processes, it was speculated that PD may be subclinically exposed to toxins and subsequently lead to age-related deities