论文部分内容阅读
α-戊基肉桂醛是一种较贵重的合成香料。过去一般是采取由苯甲醛和正庚醛在氢氧化钠碱性催化剂存在下经羟醛缩合反应而得,但收率较低。文献[2]报道,一分子烯醇硅醚与一分子醛或酮进行交叉羟醛缩合反应,可消除自身缩合的副产物,收率较高。本工作参考文献[2]的方法合成了α-戊基肉桂醛。先由正庚醛和三甲氯硅烷反应制备1-三甲基硅氧基正庚烯,然后,再与苯甲醛在四氯化钛催化剂作用下于室温进行羟醛缩合反应,并在酸性条件下脱水反应而制得:
Alpha amyl cinnamic aldehyde is a more expensive synthetic fragrance. The past is generally taken from benzaldehyde and n-heptanal in the presence of sodium hydroxide alkaline catalyst derived from the aldol condensation reaction, but the yield is low. The literature [2] reported that one molecule of vinyl alcohol ether and one molecule of aldehyde or ketone cross-aldol reaction can eliminate self-condensation by-products, the yield is higher. The work of reference [2] synthesis of α-amyl cinnamic aldehyde. First, n-heptanal and trimethylchlorosilane reaction of 1-trimethylsiloxy n-heptene, and then, and then with benzaldehyde titanium tetrachloride catalyst at room temperature for aldol condensation reaction and under acidic conditions Dehydration reaction and obtained: