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膜联蛋白(Annexins)是一类钙依赖的磷脂结合蛋白超家族,具有多种生物学功能,参与信号转导、炎性反应、细胞凋亡、细胞分泌、纤维蛋白溶解及抗凝、磷脂化、钙离子通道形成、囊泡运输、胞吐作用、细胞分化和细胞骨架蛋白间的相互作用等多个生理途径。动脉粥样硬化(Atherosclerosis,AS)现广泛认为是一种炎性病理过程,其发生、发展的整个过程都有炎性因素的参与。细胞凋亡是AS病变的主要特征。研究发现,膜联蛋白与炎症、肿瘤、AS、糖尿病等多种疾病的病理过程有密切关系,本文就其近年来在AS的研究进展及临床应用进行着重阐述。
Annexins are a class of calcium-dependent phospholipid-binding protein superfamilies that have multiple biological functions and are involved in signal transduction, inflammatory response, apoptosis, cell secretion, fibrinolysis and anticoagulation, phospholipidization , Calcium channel formation, vesicular transport, exocytosis, cell differentiation and the interaction between cytoskeletal proteins and other physiological pathways. Atherosclerosis (AS) is now widely recognized as an inflammatory pathological process, the occurrence and development of the entire process has the involvement of inflammatory factors. Apoptosis is a major feature of AS lesions. The study found that annexin and inflammation, cancer, AS, diabetes and other diseases are closely related to the pathological process, this article in recent years in AS research progress and clinical applications are highlighted.