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尽管新生儿免疫能力不如儿童和成人,但是,罹患曲菌病仍属罕见。现报告一例。女,1240g,孕31周,自然分娩,因出生后呼吸困难,采用呼吸器、激素及广谱抗生素等处理,出生后2～25天,外周血象白细胞高至40000脑脊液中蛋白高至285mg/dl,糖降低43mg/dl(血糖162mg/dl),CT提示:右侧脑脓肿;左侧脑室扩大。尽管血和CSF多次培养阴性,仍采用各种有效抗生素,同时抽吸脓液减压及培养,至出生后31天,脓液培养曲霉菌阳性,故停用各种抗生素,静脉滴注二性霉素B,并采用每日每公斤增加1mg滴注方法,同时口服利福平,剂量按15mg/kg/天。右脑脓肿及左侧脑室中也注入二性霉素B,右
Although newborns are less immunocompetent than children and adults, the prevalence of aspergillosis is still rare. Now report a case. Female 1240g pregnant 31 weeks, natural childbirth, breathing difficulties due to birth, the use of respirators, hormones and broad-spectrum antibiotics and other treatment, 2 to 25 days after birth, peripheral blood leukocytes as high as 40,000 cerebrospinal fluid protein up to 285mg / dl , Sugar reduced 43mg / dl (blood glucose 162mg / dl), CT tips: right brain abscess; left ventricular enlargement. Despite the blood and CSF culture negative many times, still using a variety of effective antibiotics, while pus vacuum suction and culture, to 31 days after birth, pus culture Aspergillus positive, it disables the use of various antibiotics, intravenous infusion of two Amphotericin B, and the daily increase of 1mg per kilogram infusion method, while oral rifampicin, the dose by 15mg / kg / day. Right brain abscess and left ventricle are also injected amphotericin B, right